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Examples of anabolic steroids available in the use are: oxymetholone (Anadrol-50) fluoxymesterone (Android-F, Halotestin, and Ora-Testryl brand names are discontinued)deca-aminobenzoate (Nexium brand names are discontinued) triiodothyronine (T3-T4; T2-T3 brands are discontinued) and trasenal (T3; T4; and T5 brand names are discontinued). Anabolic steroids also exist in a wide range of molecular weights. However, the major metabolite, dihydrotestosterone (DHT), is one of the most widely used and extensively studied steroid in humans and can represent a significant percentage of testosterone in the body . The development of a standardized method for analyzing urinary DHT has been a primary focus of attention for years [5, 6]. Determination of the urinary concentration of DHT is critical to understanding the pharmacology of steroid steroids and the relationship to medical conditions. For example, DHT, although typically a less potent male sex steroid than testosterone, can be the primary metabolite of some medications and can significantly augment the actions of a drug that is primarily designed to inhibit the activity of testosterone in the body. Therefore, DHT is often used in the treatment of testosterone receptor-positive conditions and conditions that are either testosterone- or androgen-dependent (such as breast cancer and prostate cancer). DHT is easily formed in the urine of men and is known to vary in concentration, dose, and tissue distribution in men because of the wide ranges in body fat and skeletal muscle mass, as well as the high level of muscle mass of men. DHT is rapidly transformed to inactive metabolites and may reach a maximum concentration in the urinary system within 3–7 hours in men [4, 8, 13, 14], indicating rapid conversion into active metabolites, including prostaglandins and glucocorticoids. In a recent study of men, the mean duration for urinary concentration of DHT was 1.0–3.0 hours in two men and 8.5 hours in three men . The concentration of testosterone in the urine is also a function of dietary intake for men, based on published data . DHT is not easily metabolized in humans, and there have been no reports of the conversion of active DHT to inactive metabolites in either humans or animals [4, 8, 14, 15]. Because it is metabolized predominantly by cytochrome P450 (CYP) enzymes, it is difficult to study the effects of the use of specific pharmacologic agents that target these enzymes . There is no evidence for adverse reactions to or Similar articles: